Effects of Purified Indian Cattle Tick <i>Rhipicephalus microplus</i> Saliva Toxins on Various Enzymes in Blood Serum, Liver and Muscles of Albino Mice

In the present investigation, in vivo effects of purified ticks’ saliva toxin were evaluated on level certain important cellular metabolic enzymes i.e. acid phosphatase (ACP), alkaline (ALP), glutamate pyruvate transaminase, oxaloacetate transaminase and lactic dehydrogenase. For this purpose, sub-lethal doses, 40% 80% 24 h LD50 toxins Rhipicephalus microplus (Canestrini, 1888) injected subcutaneously albino mice. treated mice targeted membrane-bound serum phosphatase, its was increased from 118.30% to 163.63% at 6th hr comparison control. Besides this, levels (GPT) (GOT) dehydrogenase (LDH) also up 161.11% (at hr), 148.27 8th hr) 125.45% respectively An increase LDH showed insufficient oxygen supply, massive disintegration cells leakage enzyme into circulation. It clearly indicated toxic membrane blood cells, hepatocytes myocardial muscle cell functions On other hand activity acetyl cholinesterase reduced by 65.51% injection This inhibition caused accumulation acetylcholine molecules synaptic junctions led prolonged activation receptors. permanent stimulation nerves that may result muscular paralysis finally death animal.